(R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands

Ian Egle; Neil MacLean; Lidia Demchyshyn; Louise Edwards; Abdelmalik Slassi; Ashok Tehim

doi:10.1016/s0960-894x(03)00779-0

(R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3419-21. doi: 10.1016/s0960-894x(03)00779-0.

Authors

Ian Egle¹, Neil MacLean, Lidia Demchyshyn, Louise Edwards, Abdelmalik Slassi, Ashok Tehim

Affiliation

¹ NPS Pharmaceuticals Inc., 6850 Goreway Dr., Mississauga, Ontario, Canada L4V 1V7. iegle@npsp.com

PMID: 14505640
DOI: 10.1016/s0960-894x(03)00779-0

Abstract

A series of (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) have been prepared using parallel synthesis, and their structure-activity relationship studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.

MeSH terms

Humans
Ligands
Pyridines / chemical synthesis
Pyridines / chemistry*
Pyridines / metabolism
Receptor, Serotonin, 5-HT1B / metabolism*
Receptor, Serotonin, 5-HT1D / metabolism*
Structure-Activity Relationship

Substances

Ligands
Pyridines
Receptor, Serotonin, 5-HT1B
Receptor, Serotonin, 5-HT1D